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Sildenafil is a potent and selective inhibitor of cGMP specific phosphodiesterase type 5 PDE5 in the corpus cavernosum, by enabling greater blood flow to the penis. Sildenafil is a drug used to treat erectile dysfunction, producing smooth muscle relaxation in the corpus cavernosum and allowing inflow of blood. Studies in vitro have shown that sildenafil is selective for PDE5, over- the- counter medicines and natural products. Take a 10mg or 20mg tablet at least 30 minutes before sexual activity.

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